From the East: Assuming that you are coming via Chicago, take either the I-88 tollway or I-80 West until you pass the Mississipi
river within the Quad Cities area (Moline and Rock Island on the Illinois side, and Davenport and Bettendorf on the Iowa side).
Continue until you connect with I-80 travelling West. Then continue on until you come to Iowa City.
Take Dubuque St. exit 244 going South and you will come to the heart of Iowa City.
From the West: Assuming that you pass through Des Moines, connect to I-80 on the north edge of Des Moines and take I-80 East
until you come to Iowa City. Take the Dubuque St. South exit 244 as above.
From the North: From Cedar Rapids, Cedar Falls and Waterloo, take I-380 South, turning onto I-80 East and then the
Dubuque St South exit 244.
From Madison, Wisconsin, connect to US-18 East/West Beltline Hwy/US-12 East. Merge onto I-39 South tollway towards Chicago via exit 267A,
merge onto I-88 West tollway via exit 97B towards the Quad Cities (Moline and Rock Island), merge onto I-80 West via exit 1B towards
Des Moines. Continue on I-80 West across the Mississippi River until you reach the Iowa City Dubuque St South exit 244.
From Minneapolis/St Paul, connect to MN-65 South, which becomes I-35W South and eventually I-35 South. take US-18 exit 190
towards Mason City/Charles City and merge onto IA-27 South. Take US-218 South ramp towards Broadway St. and merge onto IA-57 East --
in about 9 miles this becomes US-218 South, and merges with IA-27 going to Cedar Rapids/Dubuque. US-218 (which becomes I-380 near
Cedar Falls/Waterloo) continues South to I-80. Take exit 0A from US-218/I-350 towards Iowa City, and take the Dubuque St South exit 244.
From the South: From St. Louis, take I-55 North to Illinois, merge with I-155/IL-121 via exit 127 (towards Peoria),
merge onto I-74 West (towards Peoria). Continue on to the Quad Cities and where I-74 becomes I-80 and continue West until the Iowa
City Dubuque St South exit 244.
From Kansas City, take US-71 North towards I-70 West/I-29 North/I-35 North. Take I-35 North towards Des Moines, merging with
I-80 East. Continue East to Iowa City, taking the Dubuque St South exit 244.
Additionally, Mapquest is always a good option --
The University of Iowa also has some local maps and directions.